The cyclic AMP/protein kinase A (cAMP/PKA) pathway is one of the most common and versatile signal pathways in eukaryotic cells. A-kinase anchoring proteins (AKAPs) target PKA to specific substrates ...

This is linked to uncontrolled calcium influx into SCN neurons and an unregulated protein kinase A (PKA) – calcium/calmodulin-dependent kinase (CaMK) – cAMP response element-binding protein (CREB) ...

According to a new study published in the journal Cellular Signalling, cannabinoids may play a crucial role in preventing and treating brain diseases by regulating key physiological processes in the ...

Cyclin-dependent kinases ... For example, 45 human protein kinases lack at least one of the conserved catalytic residues 2 and may not have kinase activity. Kinase activity has not been detected ...

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, Colorado 80045, ...

A new study, "Identifying Allosteric Hotspots in Mycobacterium tuberculosis cAMP Receptor Protein" published in Biochemistry, provides key insights into how bacterial cAMP receptor proteins (CRPs ...

One of the best studied signalling routes is the mitogen activated protein (MAP) kinase signal transduction pathway which plays a crucial role in many aspects of immune mediated inflammatory responses ...

Figure 1. Full activation of MGP (matrix Gla protein) requires 2 posttranslational modifications, that is, vitamin K–dependent carboxylation of glutamate at positions 2, 37, 41, 48, and 52 and serine ...

RNA binding proteins (RBPs) containing intrinsically disordered regions (IDRs) are present in diverse molecular complexes where they function as dynamic regulators. Their characteristics promote ...

Your body produces the enzyme creatine kinase (CK) or creatine phosphokinase to keep your muscles functioning properly. Healthcare providers use the CK test to check levels of this protein in your ...

In cancers, all translocations involving ALK produce fusion proteins with constitutive tyrosine kinase activity that in most cases derives from spontaneous dimerization induced by the different ...

Claret and the Vietnam Education Foundation to TTV. We thank Tamara K. Locke for editing the manuscript. ADCC, antibody-dependent cellular cytotoxicity; Akt, protein kinase B; c-Cbl, Casitas B-lineage ...