AMP or ADP (adenosine-5'-diphosphate) then binds the γ subunit of AMPK and activates the kinase by 3 main mechanisms: allosteric activation of the α catalytic subunit, enhanced phosphorylation of the ...

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase first identified in a chromosomal translocation associated with some anaplastic large cell lymphomas (ALCL), a subset of T-cell non ...

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, Colorado 80045, ...