Diabetes. 2005;54(6):1615-1625. The polyol pathway, shown schematically in Fig. 2, focuses on the enzyme aldose reductase. Aldose reductase normally has the function of reducing toxic aldehydes in ...

So-called diabetic cardiomyopathy may affect up to 20% of people with chronic diabetes and represents a unique target for treatment. In this interview, James Januzzi, MD, FACC, and Alison L. Bailey, ...

Treatment with AT-001, a highly selective aldose reductase inhibitor, had no significant effect on exercise capacity as measured by peak oxygen uptake (VO2) among individuals with diabetic ...

Oral protein kinase Cβ2/1 inhibitor, ruboxistaurin. - More effective aldose reductase inhibitors. Benfothiamine. Inhibitors of leukostasis, such as anti-inflammatory agents. Use of hyaluronidase ...

The Israelites were near their last encampment and would soon cross the Jordan River to enter into the promised land. Some of them had been children when, with their parents, they had left Egypt; ...

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We have explained various metabolic abnormalities caused by hyperlipidemia, hyperglycemia, polyol signaling pathway, AGEs formation, PKC pathway, and hemosome pathway for enhanced generation of ROS, ...

Working with a diverse panel of rice accessions grown in field conditions, this valuable study measures changes in transcript abundance, tests for patterns of selection on gene expression, and maps ...

Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, 35043 Marburg, Germany Center for Synthetic Microbiology (SYNMIKRO), 35043 Marburg, Germany ...

Percentage completion of each pathway is indicated in shades of green ... The gene for NADH-dependent sulfoacetaldehyde reductase, the enzyme that catalyzes the conversion of sulfoacetaldehyde to ...

In neonatal mammals, arginine is synthesized in the enterocyte, with either proline or glutamate as the dietary precursor. We have shown several times in piglets that proline is the only precursor ...