Diabetes. 2005;54(6):1615-1625. The polyol pathway, shown schematically in Fig. 2, focuses on the enzyme aldose reductase. Aldose reductase normally has the function of reducing toxic aldehydes in ...

Oral protein kinase Cβ2/1 inhibitor, ruboxistaurin. - More effective aldose reductase inhibitors. Benfothiamine. Inhibitors of leukostasis, such as anti-inflammatory agents. Use of hyaluronidase ...

Department of Chemistry, Engineering Center of Catalysis and Synthesis for Chiral Molecules, Fudan University, 220 Handan Road, Shanghai 200433, P. R. China Shanghai Engineering Research Center of ...

So-called diabetic cardiomyopathy may affect up to 20% of people with chronic diabetes and represents a unique target for treatment. In this interview, James Januzzi, MD, FACC, and Alison L. Bailey, ...

The main pathway for the formation of AGEs. The condensation of the carbonyl group of ... activation of the glyoxalase detoxification system; and F. inhibition of aldose reductase. For exogenous AGEs ...

Various strategies used to ameliorate simultaneous mixed-sugar fermentation, including pathway introduction and optimization ... TAL, transaldolase; XR, xylose reductase; XDH, xylose dehydrogenase; ...