Diabetes. 2005;54(6):1615-1625. The polyol pathway, shown schematically in Fig. 2, focuses on the enzyme aldose reductase. Aldose reductase normally has the function of reducing toxic aldehydes in ...

Oral protein kinase Cβ2/1 inhibitor, ruboxistaurin. - More effective aldose reductase inhibitors. Benfothiamine. Inhibitors of leukostasis, such as anti-inflammatory agents. Use of hyaluronidase ...