A University of Ottawa neuroscientist has led a Canadian research team to reveal important new insights into the activation dynamics of neural stem cells (NSCs). These are the stem cells that build ...

Lastly, in vitro knockout experiments revealed the necessity for both JPT2 and LSM12 for not only unlocking calcium signaling but also other NAADP-dependent cellular functions. When the researchers ...

This paper highlights the use of SMART in several biological test cases including cellular mechanotransduction, calcium signaling in neurons and cardiomyocytes, and adenosine triphosphate synthesis.

"We also suspect that this enables this weak calcium signal to spread from cell to cell without disrupting other signaling calcium-dependent processes that are occurring simultaneously in these ...

These mutations significantly reduce the proteins' membrane expression and synaptic targeting but do not impair calcium channel activity or trans-synaptic signaling. Conducted at Karl Landsteiner ...