Using a calcium indicator, the team uncovered novel cellular behaviors tied to electrical signaling, shedding light on how early multicellular organisms sensed and responded to environmental stimuli.

They found that both proteins interacted with TPC in an independent manner. Lastly, in vitro knockout experiments revealed the necessity for both JPT2 and LSM12 for not only unlocking calcium ...

"We also suspect that this enables this weak calcium signal to spread from cell to cell without disrupting other signaling calcium-dependent processes that are occurring simultaneously in these ...

These mutations significantly reduce the proteins' membrane expression and synaptic targeting but do not impair calcium channel activity or trans-synaptic signaling. Conducted at Karl Landsteiner ...