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Clinical research suggests that combining a novel agent called navtemadlin with DNA-damaging chemotherapy for the treatment of glioblastoma, a form of brain cancer, could increase efficacy.

CMRI researchers discovered that DNA repair pathways control how cancer cells die after radiotherapy. Blocking a key repair ...

Chinese scientists unveil breakthrough therapy that could save lives from nuclear fallout - Therapy may also help control ...

Johns Hopkins University School of Medicine researchers have discovered a dual regulatory mechanism safeguarding ...

Researchers at the University of Michigan have identified how mitochondrial dysfunction impairs insulin-producing pancreatic ...

These variants control several common biological pathways, including those governing whether and how well a cell can repair damage to its DNA, how it produces energy, and how it interacts with and ...

Window of opportunity trial reveals mechanisms of response and resistance to navtemadlin in patients with recurrent ...

Both Tabrizi and Yang think that knocking down MSH3 could stave off HD pathology. Tabrizi noted that MSH3 also modifies other run-on repeats, including those causing fragile X syndrome, myotonic ...

Mitochondrial stress disrupts insulin production in diabetes, but reversing the damage may restore β-cell function.