In preliminary studies, we discovered that selected typical and atypical antipsychotic drugs interacted with virtually every biogenic amine receptor tested, in confirmation of many prior studies ...

Handling histamine intolerance can be difficult, especially if you enjoy eating foods high in histamine. Side effects like headaches, hives, and gastrointestinal problems can quickly spoil your day.

Abstract and Introduction Predicting and Establishing the Clinical Efficacy of a Histamine H Application of the Model Paradigm Conclusions References In vitro findings may correlate with the ...

While it should be noted that scientists aren't entirely sure how pitolisant works — beyond its ability to affect histamine signalling, by binding to H3 receptors (increased histamine levels are ...

Signaling by type I cytokines involves the formation of receptor homodimers, heterodimers or higher order receptor oligomers. Here we report the cloning of a type I cytokine receptor subunit that ...

histamine, glutamate and muscarinic receptors. There is clinical evidence that antipsychotic use decreases BMD and increases fracture risk, with dopamine, serotonin and adrenergic receptor-signalling ...

This study uses a wide range of approaches to identify acylation as a key regulator of Orai1 channel activation and calcium entry. The results show a novel role for Orai1 acylation in promoting ...

This mechanism starts when the α1-adrenergic receptor, a protein at the surface of the cell, detects noradrenaline molecules. However, on its own, the α1-adrenergic receptor is unable to create an ...

G protein-coupled receptors (GPCRs) are seven-transmembrane proteins that participate in many aspects of the endocrine function and are important targets for drug development. They transduce signals ...