CNN's Cooper Loses Composure in Heated Debate** In a shocking display of partisanship, CNN's Anderson Cooper resorted to name-calling during a dis ...

Kinases are enzymes that catalyze the addition of a phosphate group (PO43−) to substrates, usually proteins. The phosphate generally comes from adenosine triphosphate (ATP). Kinases and ...

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase first identified in a chromosomal translocation associated with some anaplastic large cell lymphomas (ALCL), a subset of T-cell non ...

PIM-1 kinase, a proto-oncogene-encoded serine/threonine kinase ... Results were averaged from three independent runs, with the most favorable poses serving as simulation starting points. Lys-67, ...

was based on sequence alignment with well-characterized protein kinase sequences. An insertion domain in the RLCK XI members was identified between the conserved motifs Asp-Phe-Gly (DFG) and ...

We show that V600E is the only single nucleotide substitution (Asp, Lys, and Arg, require two bases substitutions) that opens the AS through destabilization of autoinhibitory interactions, without ...