The cyclic AMP/protein kinase A (cAMP/PKA) pathway is one of the most common and versatile signal ... Peripherally induced Tregs express cyclooxygenase-2, secrete PGE 2, and elicit the ...

A catalytic mechanism is the sequence of elementary reactions by which a catalytic reaction proceeds. The behaviour of nanoconfined water can be very different from that of the bulk and is ...

Plants live under various biotic and abiotic stress conditions, and to cope with the adversity and severity of these conditions, they have developed well-established resistance mechanisms. These ...

Your body produces the enzyme creatine kinase (CK) or creatine phosphokinase to keep your muscles functioning properly. Healthcare providers use the CK test to check levels of this protein in your ...

Laboratory of Computer-Aided Molecular Design, Division of Medicinal Chemistry, Otto-Loewi Research Center, Medical University of Graz, Neue Stiftingtalstr. 6/III, A-8010 Graz, Austria ...

The study of catalysis is fundamental to understanding chemical reactions, and work in this field underpins advancements in both biological systems and industrial processes. ACS Catalysis focuses on ...

Greatwall, a conserved MAST-like kinase with crucial mitotic entry functions ... The worm PP2A-B55 phosphatase complex contains the B55 subunit SUR-6 (green), the scaffold PAA-1 (blue), and the ...

The proposed mechanism is conceptually novel in several ways, suggesting that the kinase is dual specificity (tyrosine and serine ... It is also well-established that its non-catalytic scaffolding ...

This is a well-written manuscript on the mechanism of the DFG flip in kinases. This conformational change is important for the toggling of kinases between active (DFG-in) and inactive (DFG-out) states ...

On the other hand, mechanisms of acquired resistance to 'pathway-targeted' drugs, such as the various clinically active kinase inhibitors, have been somewhat more straightforward to elucidate and ...