Rather, several distinct signaling mechanisms appear to contribute ... interact with and activate c-Src via the catalytic domain of the kinase (Ma et al., 2000). While over-expression of ...

Protein kinase inhibitors have therefore ... shed light on TIM-063's binding to AAK1's catalytic domain, offering insights into its inhibitory mechanism. By elucidating the binding of TIM-063 ...

This mutation drives uncontrolled cell growth by creating a hyperactive enzyme, Abl1 kinase ... mechanisms remain incompletely understood. For example, variations in the enzyme’s catalytic ...