The dysregulation of protein kinase ... Molecular dynamics simulations and MM/PBSA analysis further validated the strong interactions between the designed compounds and their targets, sowing the seeds ...

E1s and E2s first work generically across the cell to activate and prepare ubiquitin for attachment. E3 ligases then ensure that the tag is added to the right protein; as such, hundreds of specific ...

The cyclic AMP/protein kinase A (cAMP/PKA) pathway is one of the most common and versatile signal pathways in eukaryotic cells. A-kinase anchoring proteins (AKAPs) target PKA to specific substrates ...

eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that ...

Department of Pharmaceutical Sciences and Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China ...

The anaplastic lymphoma kinase (ALK) is the oncogene of most anaplastic large cell lymphomas (ALCL), driving transformation through many molecular mechanisms. In this Review, we will analyse how ...

Your body produces the enzyme creatine kinase (CK) or creatine phosphokinase to keep your muscles functioning properly. Healthcare providers use the CK test to check levels of this protein in your ...

According to a new study from the Lippincott-Schwartz Lab, a network of subcellular structures similar to those responsible ...

The study explores molecular mechanisms underlying synaptic plasticity - the strengthening or weakening of neuronal connections that enable learning and memory.

Lessons from the ribosome: A reflection on collaboration The ribosome’s structure exemplifies the complexity and beauty of molecular biology. Unravelling it required international collaboration ...