Mechanistically, Acod1 suppressed osteoclast differentiation by inhibiting succinate dehydrogenase-dependent production of reactive oxygen species and Hif1α-mediated induction of aerobic glycolysis.

Less than 5% of GI stromal tumors (GISTs) are driven by the loss of the succinate dehydrogenase (SDH) complex, resulting in a pervasive DNA hypermethylation pattern that leads to unique clinical ...

2019). Briefly, monocytes/macrophages were treated with 20 mM ethyl succinate or left untreated. Four biological replicates were included in each group. Protein concentration were measured with ...

The interaction formed by the terminal group varied between inhibitors and, in general, the terminal group of the most potent inhibitors tended to exhibit more interactions than weaker ones.