Kinases are enzymes that catalyze the addition of a phosphate group (PO43−) to substrates, usually proteins. The phosphate generally comes from adenosine triphosphate (ATP). Kinases and ...
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase first identified in a chromosomal translocation associated with some anaplastic large cell lymphomas (ALCL), a subset of T-cell non ...
1Division of Human Biology, Fred Hutchinson Cancer Center, Seattle, Washington. 2Division of Clinical Research, Fred Hutchinson Cancer Center, Seattle, Washington. 3Department of Laboratory Medicine ...
Particularly aberrant Cdk1 activation at the G2/M checkpoint by kinase inhibitors causing unscheduled mitotic entry and mitotic arrest was found to lead to DNA damage and cell death selectively in ...
Here, we show that the MEN activating signal at SPBs is relayed to Cdc14 in the nucleolus through the dynamic localization of its terminal kinase complex Dbf2-Mob1. Cdc15, the protein kinase that ...
Figure 2. Juvenile hormone (JH) regulation of the endoreplication. JH-Met/Tai ligand-receptor complex directly activates the expressions of cell cycle genes including minichromosome maintenance ...