Cut off any part of this worm's body and it will regrow. This is the spectacular yet mysterious regenerative ability of freshwater flatworms known as planarians. The lab of Whitehead Institute Member ...

The Wiley Foundation is pleased to announce that the 23rd annual Wiley Prize in Biomedical Sciences will be awarded to ...

These findings represent an important advance in our understanding of valve formation and the conclusions are supported by convincing data. Notch signaling has been identified as a key regulatory ...

A reduced number of master signalling pathways operate during development ... are nowadays analyzed in molecular terms. With only a handful of pathways (Fgf, Hedgehog, Wnt, TGFß, Notch among the most ...

Kuick Research Report Highlights Ongoing Developments In Molecular Switches Application Therapeutic Targets & Drug Delivery ...

We know today that Wnt and a handful of other signalling systems (Notch, Hedgehog ... agents that function by fine-tuning the Wnt pathway. This article describes major milestones that have ...

Objective To investigate whether Notch signalling contributes to the uncontrolled activation of fibroblasts in SSc. Methods Activation of the Notch pathway was assessed by immunohistochemistry or ...

In conclusion, Stat3 could be a future target for bone-related diseases. Here, we review the structure and biological function of the Stat3, the regulatory role and therapeutic prospects of targeting ...

This valuable work presents how PRDM16 plays a critical role during colloid plexus development, through regulating BMP signaling. Solid evidence supports the context-dependent gene regulatory ...

One such pathway, the hypoxic response pathway ... role in tumor growth and govern the processes of CSC survival, Notch signaling and epithelial-to-mesenchymal transition (EMT).