Feb. 13, 2025 (GLOBE NEWSWIRE) -- Agios Pharmaceuticals, Inc. (Nasdaq: AGIO), a leader in cellular metabolism and pyruvate kinase (PK) activation pioneering therapies for rare diseases, today ...

The IAEA's NUCLEUS information resource portal provides access to over 100 scientific, technical and regulatory resources, including databases, applications, publications and training material. As it ...

To investigate whether the Cdc2-like kinase 2 (CLK2) is expressed in hypothalamic ... 12 h-fasted mice were injected (i.p.) with sodium pyruvate (2 g kg −1) and blood samples were ...

FSTL1 directly binds to pyruvate kinase M2 (PKM2), inhibits ubiquitin-mediated degradation, enhances the stability of cytoplasmic PKM2 and promotes PKM2 phosphorylation and nuclear translocation in ...

These useful findings assigned a novel functional implication of histone acylation, crotonylation. Although the mechanistic insights have been provided in great detail regarding the role of the YEATS2 ...

While SPHK1 is a cytoplasmic kinase, SPHK2 is localized to the nucleus, endoplasmic reticulum, and mitochondria. The SPHK2/S1P pathway regulates transcription, telomere maintenance, mitochondrial ...

Onuf’s nucleus is a small group of neurons located in the ventral horns of the sacral spinal cord. The motor neurons (MNs) of Onuf’s nucleus innervate striated voluntary muscles of the pelvic floor ...

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Your body produces the enzyme creatine kinase (CK) or creatine phosphokinase to keep your muscles functioning properly. Healthcare providers use the CK test to check levels of this protein in your ...