The product of this tumor suppressor gene, a 105-kilodalton polypeptide called pRB, `is a cell cycle regulator. The pRB polypeptide inhibits cell proliferation by arresting cells at the G1 phase of ...

Cells were lysed with 1% SDS in 10 mM Tris, pH 7.5, and protein extracts (pRb, 10 μg; p16, 20 μg) were separated by SDS-PAGE and transferred to a nitrocellulose membrane. We stained the blots ...

Figure 2: The retinoblastoma protein phosphorylation ... into normal human somatic cells does not lead to growth transformation, does not bypass cell–cycle induced checkpoint controls and ...

Coordination of cell cycle with metabolism exists in all cell types that grow by division ... The choice of these dilutions was based on the protein concentration assay and the information retrieved ...

In a study published this month in Cellular Signaling, researchers from Osaka University have revealed that a key protein is responsible for toggling between "young" and "old" cell states.

The herpesvirus UL51 protein is a multifunctional tegument protein involved in the regulation of multiple aspects of the viral life cycle. This article reviews the biological characteristics of the ...

This valuable study reports a chemogenetic screen for resistance and sensitivity to three cell cycle inhibitors used in the clinic ... In addition to its core catalytic subunits, mutation of the ...

They found that Talin-1, a protein primarily known for its role in cell adhesion at the periphery of the cell, can also be located in the cell nucleus, where the genetic material resides.

Feb. 20, 2025 — Biologists have discovered a new type of RNA-splicing regulation that helps to determine which protein-coding exons will be included in messenger RNA ...

3 Graduate School of Biomedical Sciences at Icahn School of Medicine at Mount Sinai, New York, USA Objective Advanced hepatocellular carcinoma (HCC) is a lethal malignancy with limited treatment ...

Having the power to inhibit protein production suggests introns give cells an advantage, the researchers said. Co-author Paolo Sinopoli, a third-year molecular genetics student in Hopper's lab ...