HKO-EV (HKO empty vector control), HKO-HPK1.WT (HKO overexpressing wildtype HPK1), and HKO-HPK1.K46E (HKO overexpressing kinase-dead HPK1) Jurkat pools were generated by lenti-vector transduction. In ...

Dual luciferase reporter assays and chromatin immunoprecipitation were performed to identify whether SMAD4 functioned as a transcription factor for phosphoglycerate kinase 1 (PGK1) in PDAC cells.

Your body produces the enzyme creatine kinase (CK) or creatine phosphokinase to keep your muscles functioning properly. Healthcare providers use the CK test to check levels of this protein in your ...

Symptoms usually present in childhood or adolescence. These disorders are mostly inherited in an autosomal recessive pattern, except phosphorylase b kinase and phosphoglycerate kinase deficiencies, ...

Gene silencing is a negative feedback mechanism that regulates gene expression to define cell fate and also regulates metabolism and gene expression throughout the life of an organism. In plants, gene ...

Here, we report that the glycolytic enzyme phosphoglycerate mutase (PGAM), which converts 3-phosphoglycerate (3PG) to 2-phosphoglycerate (2PG), is physiologically upregulated in Tregs and its ...

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Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase first identified in a chromosomal translocation associated with some anaplastic large cell lymphomas (ALCL), a subset of T-cell non ...

Objectives Metabolic changes are crucially involved in osteoclast development and may contribute to bone degradation in rheumatoid arthritis (RA). The enzyme aconitate decarboxylase 1 (Acod1) is known ...

The axon initial segment (AIS) constitutes not only the site of action potential initiation, but also a hub for activity-dependent modulation of output generation. Recent studies shedding light on AIS ...

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