HKO-EV (HKO empty vector control), HKO-HPK1.WT (HKO overexpressing wildtype HPK1), and HKO-HPK1.K46E (HKO overexpressing kinase-dead HPK1) Jurkat pools were generated by lenti-vector transduction. In ...

Dual luciferase reporter assays and chromatin immunoprecipitation were performed to identify whether SMAD4 functioned as a transcription factor for phosphoglycerate kinase 1 (PGK1) in PDAC cells.

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase first identified in a chromosomal translocation associated with some anaplastic large cell lymphomas (ALCL), a subset of T-cell non ...

Here, we report that the glycolytic enzyme phosphoglycerate mutase (PGAM), which converts 3-phosphoglycerate (3PG) to 2-phosphoglycerate (2PG), is physiologically upregulated in Tregs and its ...