E1s and E2s first work generically across the cell to activate and prepare ubiquitin for attachment. E3 ligases then ensure that the tag is added to the right protein; as such, hundreds of specific ...

BYU Professor David Thomson is working to understand a chemical pathway in human muscles that may explain the effects of exercise.

The intestinal epithelium is a highly dynamic barrier that regulates digestion, absorption, immune responses, and ...

This content introduces the physiological and pathological importance of protein kinases, kinase inhibitors approved for ...

Insulin resistance precedes and predicts the onset of type 2 diabetes mellitus (DM2), a chronic disease that causes high morbidity and mortality worldwide. In affected people, insulin is unable to ...

In the case of PSKH1, which is a ‘signalling molecule’, the researchers found that when it binds to a protein called ‘Calmodulin’ PSKH1 is “switched on” and when it binds to a protein called ...

Mammalian hosts coordinate various cell death pathways as part of the immune defense system against pathogens including ...

Melbourne-based scientists have, for the first time, discovered how to "switch off" a molecule which is one of the top ...

Insulin resistance precedes and predicts the onset of type 2 diabetes mellitus (DM2), a chronic disease that causes high ...

Image supplied by WEHI. Calmodulin binds to PSKH1 (in grey) to 'switch on' PSKH1 activity. Reticulocalbin binds to PSKH1 to 'switch off' PSKH1 ...

Cystic fibrosis is a life-threatening disease predominantly with respiratory symptoms. Most of the subjects with the disease harbor the F508del variant in the CFTR gene that causes the protein to ...