This content introduces the physiological and pathological importance of protein kinases, kinase inhibitors approved for ...

The intestinal epithelium is a highly dynamic barrier that regulates digestion, absorption, immune responses, and ...

Mammalian hosts coordinate various cell death pathways as part of the immune defense system against pathogens including ...

Melbourne-based scientists have, for the first time, discovered how to "switch off" a molecule which is one of the top ...

Study shows that cannabidiol (CBD) enhances endurance exercise in mice by reshaping gut microbiota, boosting mitochondrial ...

BYU Professor David Thomson is working to understand a chemical pathway in human muscles that may explain the effects of exercise.

Previous research has shown that mammals accumulate LCA during calorie restriction and it activates a key molecule involved in metabolism called AMP-activated protein kinase, or AMPK. AMPK ...

Tyrosine phosphorylation of the EGFR leads to the recruitment of other signaling proteins including phospholipase Cγ and the non-receptor tyrosine kinase c-Src. EGFR activation also leads to ...

Cystic fibrosis is a life-threatening disease predominantly with respiratory symptoms. Most of the subjects with the disease harbor the F508del variant in the CFTR gene that causes the protein to ...

Shenzhen Zhongge Biotechnology Co. Ltd. has divulged AMP-activated protein kinase α1β1γ1 activators reported to be useful for the treatment of acute kidney injury, alopecia, chronic kidney disease, ...

The Fast Track designation is supported by data from a phase 2 trial that evaluated eRapa in 30 adult patients with FAP.

Greatwall, a conserved MAST-like kinase with crucial mitotic entry functions, is curiously absent in worms. Here, the single ...