A new study gives hope for improved treatment of prostate cancer, the second most diagnosed cancer among men worldwide.

often with cascades of phosphorylation events. Kinases are attractive drug targets, but the design of highly selective kinase inhibitors remains challenging. Here, the authors report photoaffinity ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Greatwall, a conserved MAST-like kinase with ...

Protein phosphorylation is a cornerstone of cellular communication, orchestrating rapid and precise responses to ...

Recently approved treatments for generalized myasthenia gravis (gMG), including complement and neonatal Fc receptor (FcRn) ...

Protein design (or protein engineering) is a technique by which proteins with enhanced or novel functional properties are created. Proteins can be engineered by rational design, which typically ...

Yet on a clear day, the western Cascades are our own personal snow-capped end of the world, even if we’d be hard-pressed to name more than one or two. It’s easy to take such a stunning view ...

Forecasters say an additional 11 to 15 inches could fall in the northern and central Oregon Cascades. “If your car becomes trapped in deep snow, be sure to keep your car off to stay safe from ...