T cell protein tyrosine phosphatase (TCPTP), a vital regulator in glucose metabolism, inflammatory responses, and tumor processes, is increasingly considered a promising target for disease treatments ...

Protein Tyrosine Phosphatase 1B (PTP1B) has emerged as a significant regulator of metabolic and cardiovascular disease. It is a non-transmembrane protein tyrosine phosphatase that negatively regulates ...

Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia ...

We revealed changes in transcriptional networks through gene set enrichment analysis and correlated phosphatase expression levels to patient survival and tumour recurrence. Results We demonstrate that ...

Adrenomedullin (ADM) inhibits endothelial insulin signaling, contributing to obesity-associated insulin resistance, according ...

Researchers investigate the underlying mechanisms of endothelial insulin resistance involved in obesity-associated diabetes.

A new study published in Advanced Science has revealed how curcumin, a bioactive compound found in Curcuma aromatica (Yujin), ...

综合研究结果和讨论部分，这项研究意义重大。它揭示了牙周炎和类风湿关节炎之间复杂的分子联系，找到了 PTPRC 这个潜在的关键调节因子。这不仅让我们对这两种疾病的发病机制有了更深入的理解，也为开发同时治疗这两种疾病的双靶点疗法开辟了新道路。未来，或许可以针对 PTPRC 开发药物，抑制过度的免疫反应，减轻组织损伤；还能把 PTPRC 当作生物标志物，用于疾病的早期检测和治疗效果监测，实现更精准的医疗 ...

Shenzhen Zhongge Biotechnology Co. Ltd. has disclosed tyrosine-protein phosphatase non-receptor type 2 (PTPN2; TCPTP) inhibitors reported to be useful for the treatment of cancer.

Suzhou Genhouse Bio Co. Ltd. has disclosed tyrosine-protein phosphatase non-receptor type 11 (PTPN11; PTP-2C; SHP-2) inhibitors reported to be useful for the treatment of cancer, Noonan syndrome and ...

Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...