Understanding the molecular mechanisms of insulin resistance remains a major medical challenge of the twenty-first century. Over the last half-century, many hypotheses have been proposed to ...

According to Dr. Gerald I. Shulman, a leading diabetes researcher at Yale School of Medicine, the answer is yes. “If you reverse insulin resistance, you reverse type 2 diabetes,” he explains.

Surrogate insulin resistance measures short of the “gold standard” were able to predict OA. Triglyceride-glucose index combined with waist-height ratio had greatest diagnostic efficacy.

Insulin resistance drives type 2 diabetes, Shulman explains. "If you reverse insulin resistance, you reverse type 2 diabetes," he said. In a landmark study, Shulman and Kitt Petersen, MD ...

Although insulin resistance (IR) is a key pathophysiologic condition underlying various metabolic ... that are not endogenous were added at this stage to further control for RT-qPCR efficiency.