However there has been no indication from Cbl's sequence that it contained an SH2 domain — the archetypal phospho-tyrosine binding motif. Consequently the recent structure of Cbl from Michael ...

In contrast to PTB domains, the structurally distinct SH2 domains are highly specialized for the recognition of pTyr. Specificities of binding for individual SH2 domains can in many cases be ...

Signal transducer and activator of transcription 6 (STAT6) is a member of the STAT family involved in the regulation of immune response and inflammation. The development of SH2 domain inhibitors ...