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5 小时
DPD 缺陷对卡培他滨和 5-氟尿嘧啶治疗有哪些影响?
二氢嘧啶脱氢酶(DPD)在 5-氟尿嘧啶(5-FU)及其前药卡培他滨的代谢中发挥着关键作用。DPD 是氟尿嘧啶代谢的限速酶,负责将其转化为无活性的代谢物。研究表明,DPD 的缺陷会导致 5-FU ...
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