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类器官周报|帕金森病神经退变与T细胞-中脑类器官共培养模型
为攻克这一难题,研究团队开发了一种三维共培养模型,将人类中脑类器官(hMO)与外周血T细胞结合。研究人员首先从健康供体的成纤维细胞入手,将其转化为诱导多能干细胞(hiPSC),并诱导分化为hMO。这些类器官稳定表达中脑特异性标记物,为后续研究提供了可 ...
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