- Allylation of aldehydes is one of the most important organic transformations that helps in the synthesis of compounds with special skeletons with unique medicinal properties.www.sciencedirect.com/science/article/pii/S2211715624005435
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18.4: Alkylation of Aldehydes and Ketones - Chemistry LibreTexts
Overall an α hydrogen is replaced with an alkyl group. This reaction is one of the more important for enolates because a carbon-carbon bond is formed. These alkylations are affected by the same limitations as S N 2 reactions previously discussed. A good leaving group, Chloride, Bromide, …
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Direct β-Alkylation of Aldehydes via Photoredox …
Apr 22, 2014 · Direct β-alkylation of saturated aldehydes has been accomplished by synergistically combining photoredox catalysis and organocatalysis. Photon …
- Author: Jack A. Terrett, Michael D. Clift, David W. C. MacMillan
- Publish Year: 2014
Asymmetric α-Alkylation of Aldehydes, Ketones, and …
Sep 24, 2013 · The α-alkylation of aldehydes and ketones is fundamental to synthetic organic chemistry. Although electrophilic addition to derived enolates is a viable means of achieving this transformation in the case of ketones, it is not …
Merging Photoredox Catalysis with Organocatalysis: …
Oct 3, 2008 · Specifically, the enantioselective intermolecular α-alkylation of aldehydes has been accomplished using an interwoven activation pathway that combines both the photoredox catalyst Ru (bpy) 3 Cl 2 (where bpy is 2,2′ …
Jun 26, 2017 · Here, we show that the synergistic merger of three catalytic processes—photoredox, enamine and hydrogen-atom transfer (HAT) catalysis enables an …
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Direct Aldehyde C–H Arylation and Alkylation via the Combination …
A mechanism that enables direct aldehyde C–H functionalization has been achieved via the synergistic merger of photoredox, nickel, and hydrogen atom transfer (HAT) catalysis. This …
Direct, enantioselective α-alkylation of aldehydes using simple …
Here, we show that the synergistic merger of three catalytic processes—photoredox, enamine and hydrogen-atom transfer (HAT) catalysis—enables an enantioselective α-aldehyde alkylation reaction that employs simple olefins as coupling partners.
Direct Aldehyde C–H Arylation and Alkylation via the …
Aug 6, 2017 · A mechanism that enables direct aldehyde C–H functionalization has been achieved via the synergistic merger of photoredox, nickel, and hydrogen atom transfer catalysis. This mild, operationally sim...
Radical-Mediated α- tert -Alkylation of Aldehydes by …
May 28, 2024 · In this study, we present a novel radical-mediated tert -alkylation approach targeting the α-position of aldehydes, enabling the synthesis of complex aliphatic aldehydes.
Direct, enantioselective α-alkylation of aldehydes using ... - Nature
Jun 26, 2017 · Here, we show that the synergistic merger of three catalytic processes—photoredox, enamine and hydrogen-atom transfer (HAT) catalysis—enables an …
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