Defining ‘T cell exhaustion’ | Nature Reviews Immunology
2019年9月30日 · ‘T cell exhaustion’ is a broad term that has been used to describe the response of T cells to chronic antigen stimulation, first in the setting of chronic viral infection but more...
The current state and future of T-cell exhaustion research
With the help of these new approaches, it is now known that exhausted T cells comprise distinct immune cell types of a specific lineage that differ from effector or memory T cells and play a …
T-cell exhaustion: characteristics, causes and conversion
Exhausted T cells express arrays of inhibitory molecules and distinctive patterns of cytokine receptors, transcription factors and effector molecules, which distinguish these cells from …
Dysfunction of exhausted T cells is enforced by MCT11-mediated …
2024年11月8日 · Exhausted T (T ex) cells are characterized by upregulation of coinhibitory molecules and reduced polyfunctionality. T cells in the TME experience an …
T cell exhaustion - Nature Immunology
2011年5月18日 · Exhaustion prevents optimal control of infection and tumors. Recently, a clearer picture of the functional and phenotypic profile of exhausted T cells has emerged and T cell …
Molecular and cellular insights into T cell exhaustion - PMC
Exhausted T cells lose robust effector functions, express multiple inhibitory receptors and are defined by an altered transcriptional programme. T cell exhaustion is often associated with …
Decoding and overcoming T cell exhaustion: Epigenetic and ... - Cell …
2024年6月5日 · Key transcription factors, such as TCF1, BACH2, and TOX, are crucial for defining and sustaining exhaustion phenotypes. Concurrently, epigenetic regulators, such as …
Cellular and molecular waypoints along the path of T cell …
2023年9月1日 · Thirty years of foundational research investigating molecular and cellular mechanisms promoting T cell exhaustion are now enabling rational design of T cell–based …
Charting the Roadmap of T Cell Exhaustion - Cell Press
2020年5月19日 · Exposure to chronic infection or malignant tumors triggers the differentiation of functionally impaired, so-called exhausted T cells. In this issue of Immunity, Beltra et al. reveal …
Mitochondrial dysfunction defines T cell exhaustion
2021年3月2日 · Here, we preview findings from Scharping et al. (2021), who have illuminated the molecular mechanism by which the persistent antigen stimulation and severe hypoxic …
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