Three tissue resident macrophage subsets coexist across organs …
2022年1月7日 · They defined three recurring transcriptionally related macrophage subsets with unique core gene signatures, which can be stratified based on expression of TIMD4, LYVE1, FOLR2, CCR2, and MHC-II.
Tissue-resident FOLR2+ macrophages associate with CD8+ T cell …
2022年3月31日 · The density of FOLR2 + macrophages in tumors positively correlates with better patient survival. This study highlights specific roles for tumor-associated macrophage subsets and paves the way for subset-targeted therapeutic interventions …
Tissue-resident FOLR2+ macrophages associate with CD8+ T cell ...
2022年3月23日 · By contrast, we show that FOLR2 + macrophages are tissue-resident macrophages (TRMs) populating healthy mammary glands (MGs) prior the onset of cancer development. Specific gene signatures defining FOLR2 + macrophages correlate with better survival of patients with BC.
Single-cell profiling reveals the trajectory of FOLR2 ... - Nature
2023年8月2日 · Myeloid cells and T cells were the most abundant cell types in tumors and normal lung tissues, while tumor-associated macrophage-folate receptor 2 (TAM-FOLR2) and CD4 + nuclear receptor...
FOLR2 + macrophage depletion from intestinal metaplasia to …
2024年12月19日 · FOLR2+ macrophages were significantly positively correlated with CD8+ T cells and activated the cytotoxicity of CD8+ T cells via antigen cross-presentation. Additionally, during the progression of EGC, epithelial cells progressively upregulated APP expression, thus inducing necroptosis of FOLR2+ macrophages via the APP‒TNFRSF21 axis.
FOLR2 + macrophage depletion from intestinal metaplasia to …
2024年12月19日 · Results: Five subpopulations of macrophages were identified in CIM, IIM and EGC samples. FOLR2 + macrophages possess antitumor immune potential, and the proportion of FOLR2 + macrophage gradually decreased from the CIM stage to the IIM and EGC stages.
Folate Receptor β (FRβ) Expression in Tissue-Resident and Tumor ...
More specifically, FOLR2 expression has been found to strongly correlate with the expression of M-MØ-specific genes in tissue-resident macrophages, tumor-associated macrophages (TAM) and macrophages from inflamed synovium, and also correlates with the presence of the PU.1 transcription factor.
WNT-dependent interaction between inflammatory fibroblasts and FOLR2 …
2024年1月25日 · We demonstrate that CXCL-iFibro co-localize with macrophages in the kidney and participate in their attraction, accumulation, and switch into FOLR2+ macrophages from early CKD stages on.
FOLR2 + Macrophages Are Associated with T-cell Infiltration and ...
2022年6月2日 · Major Finding: FOLR2 + macrophages are associated with improved survival in patients with breast cancer. Concept: These tissue-resident macrophages interact with CD8 + T cells and are correlated with their infiltration. Impact: These findings suggest subtype-focused therapeutic interventions against macrophages in cancer.
Single-cell profiling reveals the trajectory of FOLR2-expressing …
Myeloid cells and T cells were the most abundant cell types in tumors and normal lung tissues, while tumor-associated macrophage-folate receptor 2 (TAM-FOLR2) and CD4 + nuclear receptor subfamily 4 group A member 3 (NR4A3) exhibited sharp increases in …