Galactokinase is an enzyme (phosphotransferase) that facilitates the phosphorylation of α-D-galactose to galactose 1-phosphate at the expense of one molecule of ATP. [1] Galactokinase catalyzes the second step of the Leloir pathway, a metabolic pathway found in most organisms for the catabolism of α-D-galactose to glucose 1-phosphate. [2]

半乳糖苷酶是指一类水解含半乳糖苷键物质的酶类，如乳糖（乳糖为一分子葡萄糖与一分子半乳糖经脱水缩合形成的二糖）。主要分为α-半乳糖苷酶和β-半乳糖苷酶。α-半乳糖苷酶催化α-半乳糖苷键的水解，可将饲料及豆制食品中的抗营养因子α-半乳糖苷类转化分解，改善其营养成分。此 …

半乳糖激酶（英語： Galactokinase ）是一种催化α-D-半乳糖 磷酸化为半乳糖-1-磷酸的磷酸转移酶，在此过程中消耗一分子 ATP [1] 。 半乳糖激酶催化 Leloir途径 （有机体中将α-D-半乳糖转化为 葡萄糖-1-磷酸 的 代謝途徑 ）的第二步反应，最早在 哺乳动物 的 肝臟 中 ...

Galactokinase deficiency is an autosomal recessive metabolic disorder marked by an accumulation of galactose and galactitol secondary to the decreased conversion of galactose to galactose-1-phosphate by galactokinase. [2] The disorder is caused by mutations in the GALK1 gene, located on chromosome 17q24. [1]

This review focuses on the recent X-ray crystallographic analyses of galactokinase and places the molecular architecture of this protein in context with the extensive biochemical data that have accumulated over the last 40 years regarding this fascinating small molecule kinase.

2023年7月31日 · Galactokinase deficiency, aka galactosemia type II, is an inborn error of galactose metabolism. Galactokinase deficiency is rare and more insidious than other galactosemia types since it results in the formation of nuclear cataracts without provoking intolerance symptoms or other systemic symptoms.[1]

Galactokinase plays a key role in normal galactose metabolism by catalyzing the ATP-dependent phosphorylation of α-d-galactose to galactose 1-phosphate. In humans, mutations in the galactokinase gene can lead to the diseased state referred to as Type II galactosemia.

Galactokinase is a major Enzyme for the metabolism of galactose and its deficiency causes congenital cataracts during infancy and presenile cataracts in the adult population. [provided by RefSeq, Jul 2008]

Galactokinase deficiency is a rare, autosomal recessive trait in which high concentrations of galactose are found in the blood, particularly after a meal that includes lactose-rich foods, such as milk and non-fermented milk products. From: Essentials of Medical Biochemistry, 2011

2025年1月6日 · One of these enzymes is Gal1p, a galactokinase that catalyses the first step of GAL metabolism. Throughout the article, we refer to this signalling process that results in GAL1 expression as ...