The progression of galactosemic cataract is generally divided into three stages; initial vacuolar, late vacuolar, and nuclear cataract. The formation of a mature, nuclear, cloudy galactosemic cataract typically surfaces 14 to 15 days after the onset of the galactose diet. Fig. 6 depicts the three stages of galactosemic cataract with their ...

Galactosemia is a disorder caused by a deficiency of any one of three possible enzymes involved in the metabolism of galactose: galactokinase, transferase or epimerase. Any single deficient enzyme can result in cataract through the accumulation of galactitol in the lens.

Galactosemia and its relation to Laennec's cirrhosis; review of the literature and presentation of six additional cases. Pediatrics. 1951 Jun;7(6):760–773. [ PubMed] [ Google Scholar] RITTER JA, CANNON EJ. Galactosemia with cataracts; report of a case, with notes on physiopathology. N Engl J Med. 1955 May 5;252(18):747–752.

Galactosemia is a disorder caused by a deficiency of any one of three possible enzymes involved in the metabolism of galactose: galactokinase, transferase or epimerase. Any single deficient enzyme can result in cataract through the accumulation of galactitol in the lens. The ophthalmologist may play …

1990年3月1日 · Galactose can induce cataracts in infants with galactosemia, a congenital deficiency of the enzymes needed for galactose metabolism (figure 1). There are two forms of galactosemia: galactose-l-phosphate uridyl transferase (GPUT) deficiency galactosemia and galactokinase (GK) deficiency galactosemla.

1988年3月1日 · Galactosemia is a disorder caused by a deficiency of any one of three possible enzymes involved in the metabolism of galactose: galactokinase, transferase or epimerase. Any single deficient enzyme can result in cataract through the accumulation of galactitol in the lens.

2015年12月3日 · We sought to retrospectively review the incidence and severity of cataracts in the cohort of galactosaemia patients attending our national treatment centre and to assess a possible effect of dietary compliance on cataract formation …

Galactose accumulation in the lens tissue is known to be cataractogenic. Whether consistent dietary intake of lactose—which consists of glucose and galactose—predisposes to senile cataract remains unclear. This study was conducted to investigate the ...

A summary of the events occurring in galactose cataract is presented in Fig. 10. The primary factor initiating this type of cataract is the high concentration of galactose in the aqueous humor. The abnormal level of galactose in the lens triggers the enzyme aldose reductase to convert galactose to dulcitol.

Nuclear cataract formation is a common feature across most forms of galactosemia, except for peripheral GALE deficiencies and Duarte Galactosemia, as described below. By managing galactose intake and monitoring for ophthalmological changes, potential complications related to cataracts can be minimized.