TCR-engineered T cell therapy in solid tumors: State of the
2023年2月15日 · T cells expressing an engineered T cell receptor (TCR-T cells) represent a promising therapeutic alternative. The target repertoire is not limited to membrane proteins, and intrinsic features of TCRs such as high antigen sensitivity and near-to-physiological signaling may improve tumor cell detection and killing while improving T cell persistence.
免疫细胞治疗——TCR-T - 知乎 - 知乎专栏
TCR-T 细胞疗法： 通过筛选和鉴定能够特异性结合 靶点抗原 的TCR 序列， 采用基因工程手段将其转入到患者 外周血 来源的 T 细胞中( 或异源 T 细胞) ， 再将改造后的 T 细胞回输至患者体内， 使其 特异性识别 和杀伤表达抗原的肿瘤细胞， 从而达到治疗肿瘤的目的 ...
T-cell receptor - Wikipedia
The T-cell receptor (TCR) is a protein complex found on the surface of T cells, or T lymphocytes, [1] that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules.
T cell receptor (TCR) signaling in health and disease
2021年12月13日 · This review provides a comprehensive snapshot of the various molecules involved in regulating T cell receptor signaling, covering both enzymes and adaptors, and will discuss their role in human...
【综述】| TCR-T免疫治疗肿瘤：现状、挑战及展望-MedSci.cn
2023年9月6日 · [摘要] T细胞受体工程T细胞（engineered T cell receptor-T cell，TCR-T）疗法和嵌合抗原受体T细胞（chimeric antigens receptor-T cell，CAR-T）疗法是目前过继性T细胞治疗最有效的两种方式。由于CAR仅能识别肿瘤表面的抗原，在实体瘤治疗中至今未有令人满意的结果。
T cell receptor T cell therapy - Wikipedia
T cell receptor T cell therapy (TCR-T) is a type of adoptive T-cell therapy that targets some cancers. TCR-T therapies use heterodimers made of alpha and beta peptide chains to recognize MHC-presented polypeptide fragment molecules. Unlike CAR-T, which uses cell surface antigens, TCR-T can recognize MHC's larger set of intracellular antigen ...
T cell receptor (TCR) signaling in health and disease - PMC
Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells. The outside environmental cues are translated into various signal transduction pathways within the cell, which mediate the activation of various genes with the help of specific transcription factors.
TCR-T cell therapy: current development approaches, preclinical ...
2024年10月4日 · This review aimed to systematically outline the processes for evaluating TCR-T cells at each stage: from in silico approaches used to predict target antigens, assess cross-reactivity, and minimize off-target effects, to in vitro assays designed to measure cell functionality, cytotoxicity, and activation.
T cell receptor (TCR) signaling in health and disease - PubMed
2021年12月13日 · This review provides a comprehensive snapshot of the various molecules involved in regulating T cell receptor signaling, covering both enzymes and adaptors, and will discuss their role in human disease.
Cell Biology of T Cell Receptor Expression and Regulation
2018年4月26日 · T cell receptors (TCRs) are protein complexes formed by six different polypeptides. In most T cells, TCRs are composed of αβ subunits displaying immunoglobulin-like variable domains that recognize peptide antigens associated with major histocompatibility complex molecules expressed on the surface of …