clopidogrel before PCI. Ticagrelor, prasugrel, or clopidogrel before PCI. UFH 70 units/kg (repeat bolus by ACT) Bivalirudin (repeat bolus by ACT) Primary endpoint: at 28 days. Efficacy: MACE (Death, MI, TVR, Stroke) Safety: Major bleed (BARC 3-5) n=1,812. Started prior to PCI and continued to completion of procedure (GPI only if bailout)